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Patient Case FileAwaiting Pieper Response

Veronika Pogrebova

Fluoroquinolone-Associated Disability — treatment plan by Dr. Stefan Pieper, Integrative Medicine, Konstanz.

DOB 06.10.1992ICD E72.8Case Dec 2025Updated Mar 2026
Medication
Clonazepam 0.6mg
0.3 AM + 0.3 PM · Only tolerated med
SSRIs
BANNED
Liver damage from Cipralex · Pieper: no SSRIs ever
Ferritin
9.98
Critical · Was 4 · 4/5-6 IV done
Iron Saturation
13.19%
Low · Normal 20-50%
Bell Scale
~40
Functions but constant distress
TMS
Paused
~30 sessions · may have worsened
Vitamin D
26.1
Low · Target 40-60
GGT
54
Elevated · Liver post-Cipralex
Estrogen
Unclear
5mo amenorrhea → 2 periods · Pending labs
Age
33
DOB 06.10.1992
01 · Timeline

Case History

Jan 2024
FQ Poisoning
Hospitalised with pneumonia at Cromwell Hospital, London (private clinic). Given Levofloxacin IV for 2 days. Nobody warned about side effects. Upon discharge: immediate suicidal ideation, couldn't walk normally, severe psychiatric symptoms. Husband was shocked — she came out of hospital a different person.
Jan–Apr 2024
Acute Phase — UK to Spain
Family relocated from London to Spain (Lloret de Mar). Veronika was very ill — thought she was dying, told husband "they will take my kids." Multiple Spanish doctors recommended antidepressants — she refused all of them.
Apr 2024 – ~Apr 2025
Functional Medicine Recovery
Consulted a functional medicine doctor from New Zealand. Followed strict protocol: L-theanine, magnesium, omega-3, B complex, glutathione, iron, adrenal complex. Clean diet, no coffee, daily meditation, yoga, sports. Extremely disciplined for over a year. Gradual improvement.
Apr–Jul 2025
Near-Normal
Working, exercising, functioning almost normally. Started going to parties, drinking wine occasionally, smoking cigarettes.
Jul–Sep 2025
Relapse
After ~3 months of alcohol and cigarettes, all symptoms returned: brain fog, tiredness. Then escalated: complete insomnia (could not fall asleep at all), depression, panic attacks, suicidal thoughts. Geneva checkup: Brain EEG normal, MRI normal, but Ferritin: 4 (critical). Barcelona Delfos Clinic: during hospital sleep study she actually slept well WITHOUT medication (paradox). Visited 5 hospitals, saw 40+ doctors.
~Oct–Nov 2025
Escitalopram (Cipralex)
Doctors prescribed Clonazepam + Escitalopram 10mg. After 6 weeks on escitalopram: no improvement, felt worse. Blood work revealed liver damage: ALT ×7, AST ×5 from normal. Escitalopram stopped immediately. Took Lorazepam about 8 times for sleep during this period — caused worsening (depression, panic, fainting sensations).
10 Dec 2025
First Contact with Dr. Pieper
Anton emails kontakt@praxisdrpieper.de. Pieper replies Dec 12 — offers individual therapy plan for €293 via PayPal. Email only, no video/phone. Sends FQAD Questionnaire.
14 Dec 2025
Questionnaire + Payment Sent
Filled FQAD Questionnaire (Bell Scale: 40) + medical brief ("veronika_brief.pdf") + €293 payment. Bell 40 = can do light work 3-4 hours with rest periods.
18 Dec 2025
Pieper Sends Full Therapy Plan
Package: therapy letter with diagnosis (FQAD, ICD E72.8, GABA metabolic disorder), supplement protocol table, nicotine patch PDF with research papers (Sanders 2022, Leitzke 2023), Visual Snow PDF. Separate message: "and please don't take SSRIs anymore!!!"
End Dec 2025
Cold-Turkey Clonazepam — CRISIS
Ukrainian doctor (online consultation) told Veronika to stop clonazepam in one day. She did it against Anton's advice. Doctor gave quetiapine instead — she felt very unwell, possibly from quetiapine or from abrupt clonazepam withdrawal or both. Day 7: emergency room. Clonazepam reinstated at 0.2mg in drops.
Jan 2026
Clonazepam Tripled + ZEM + TMS
Another doctor increased clonazepam from 0.2mg to 0.6mg/day (0.3 morning + 0.3 evening) — triple the pre-crisis dose. Went to ZEM Wellness Clinic in Altea — no significant improvement, constant rumination. A neurologist started TMS (Saint Protocol).
Jan–Feb 2026
Iron Infusions + TMS Results
Labs Jan 9: Ferritin 9.98 (was 4), Iron Sat 13.19%, GGT 54, AST 39, Vit D 26.1. Started Venofer (Feriv) IV iron infusions — 4 of 5-6 completed. TMS: approximately 30 sessions — appeared to make things worse, she felt more depleted. TMS paused. No periods for 5+ months, estrogen very low. CUN Pamplona MRI/EEG/lumbar puncture scheduled then postponed.
14 Feb 2026
Anton Updates Pieper
Detailed email about the deterioration. Reported: nicotine not started, cold-turkey disaster, TMS, iron infusions, Veronika's low state. Asked about nicotine, CBT, residential programs, estrogen.
21 Feb 2026
Pieper Responds
"This sounds really dramatic and like a severe deterioration." Gives modified nicotine protocol — more cautious: ¼ patch for 2 weeks (not 3 days). Asks 9 specific questions. Offers GABA/Serotonin urine test. Later same day sends "???" — no reply from our side.
~Feb–Mar 2026
Current State Stabilised Somewhat
Rumination reduced. Still nervous, agitated, restless. Swims 3×/week, walks, but in constant anxious state. Cannot focus on children or conversations. Thinks she "forgot how to communicate." Daily online psychotherapy in Russian — therapists all say take antidepressants. Pharmacogenomics test done at CUN. Periods returned (2 in last month after 5 months absent).
23 Mar 2026
Reply Sent to Pieper
Full answers to all 9 questions + 7 additional questions + request for online consultation. Shared case file: veronika.dscff.es. Awaiting response.
📧
Reply sent March 23. Waiting for Pieper's response.
02 · Diagnosis

What Pieper Found

FindingDetail
DiagnosisFQAD — Fluoroquinolone-Associated Disability
ICDE72.8 — GABA metabolic disorder
FocusNeuropsychiatric
DrugLevofloxacin IV, 2d, Jan 2024, Cromwell Hospital London

GABA System Damage

GABA = brain's calming neurotransmitter. FQs block GABA receptors → anxiety, hypervigilance, insomnia, panic, depression.

Benzos are counterproductive. Block brain's own GABA recovery. Taper slowly — never cold-turkey.

Acetylcholine Receptor Blockage

FQ metabolites block nAChRs → cognitive fog, fatigue, mood, sleep. Proven: Sanders 2022.

Solution: Nicotine patches. 30× higher affinity. Leitzke 2023: up to complete remission.

Therapy Goals

  1. Neuroprotection
  2. Adequate sleep
  3. Strengthen GABA
  4. Wean off benzos
  5. Liberate acetylcholine receptors
  6. Hypervigilance therapy daily
03 · Step 1

Nicotine Patch Therapy

Two versions. Feb 21 is MORE CAUTIOUS. Use modified.

Original (Dec 18)

Phase 1: ¼ patch × 3 days

7mg, cover ¾ tape. + Ambroxol 75mg × 10 days.

Phase 2: ½ patch from day 4, 4 weeks

If no improvement after 4 wks → Ambroxol 10 more days.

Modified (Feb 21)

Pieper: "start very cautiously"

Phase 1: ¼ patch daily × 2 WEEKS

Much slower given deterioration.

Phase 2: ½ patch × 4 weeks

Total 4-8 wks. Report Pieper at wk 4.

Use modified (Feb 21) protocol.

Rules

  • Don't cut patches in Europe — tape
  • Side effects 3-5d normal
  • Improvement → go slowly
  • Strict pacing = no relapses
04 · Protocol

Supplements + B1 + Benzo Taper + Nervous System

RemedyAMNoonPMNightNotes
MVM-A Antioxidant11Allergy Research
D3 5000+K2 200mcg1w/ meals
Omega-3 algae2+linseed oil
CoQ10 2001+CDP-Choline 250
Mg Glycinate 100111+Ca 1-2g
Mg L-Threonate 200011-2=144mg
Spermidine 1.2mg111or wheatgerm
Theanine+Tyrosine+5HTP+Taurine1-2+Ashwagandha
SAMe 400-5001(1)+GABA 750-1000
Daridorexant 501benzo taper
Pregnenolone 501+Pomegranate
NMN 500→NAD+14-12 wks

Daily nutrition

  • MCT drink · Bone broth/Collagen 20g+VitC
  • Kefir/Kombucha+24-strain probiotic
  • GABA teas: Valerian, Passion Flower, Balm, Hops

Step 2: B1

3-wk high-dose. Neuroprotective.

Step 3: Benzo Taper (later)

0.6mg/day now. She believes clonazepam makes her worse and wants off. Tried Daridorexant briefly — had some side effects. She sleeps normally now without problems. Taper timing: waiting for Pieper's guidance.

Step 4: Hypervigilance (ongoing)

Polyvagal, somatic tracking, slow breathing.

Pieper rec.
Dr. Eleanor Stein

Neuroplasticity course

Pieper rec.
Gupta Program

Free 28d trial

iOS
Pieper rec.
CFS School

Trauma-informed

Book
Body Keeps Score

van der Kolk

05 · Diet

IF 16:8 · Low-Carb · Low-Histamine

✕ Avoid

  • ✕ Gluten
  • ✕ Sugar
  • ✕ White flour
  • ✕ Coffee
  • ✕ Alcohol
  • ✕ High-histamine
  • ✕ Non-organic
  • ✕ Farmed fish

✓ Include

  • ✓ Organic only
  • ✓ Wild fish
  • ✓ Low-carb
  • ✓ Bone broth
  • ✓ Fermented foods
  • ✓ GABA teas
  • ✓ 16:8
  • ✓ Linseed oil
06 · Restrictions

Absolute No-Go

Any = relapses + severe deterioration.
  1. No SSRIs/SNRIs — liver damage
  2. No Quetiapine
  3. No cortisone
  4. No NSAIDs
  5. No extra benzos
  6. No vaccines
  7. No antibiotics (FQs EVER)
  8. No long flights
  9. No stress
  10. No antidepressants w/o Pieper
  11. No unnecessary interventions
07 · Assessment

Visual Snow Syndrome

Veronika: review, mark matches, include in reply.

Visual

Visual Snow

Pixelated/flickering dots, TV static, all lighting.

Afterimages / Trailing

Imprints persist. Moving objects leave trails.

Floaters / Blue-Field

Cobwebs indoors. WBC on wiggly paths.

Photopsia / Photophobia

Random flashes. Light painful.

Night Blindness / Halos / Starbursts / Glare / Ghosting

Low light trouble. Circles/rays. Ghost images.

Pulsating / Flickering / Contrast / Pattern Glare

Heartbeat vision. Heat-haze. Washed out. Patterns shimmer.

Non-Visual

Tinnitus

62% of VS patients.

Depersonalization / Derealization / Brain Fog

Detached. Dreamlike. Confusion.

Vertigo / Tremor / Twitching

Spinning. Involuntary.

08 · Correspondence

Questions Between Us & Dr. Pieper

📧
Reply sent March 23, 2026. Awaiting Pieper's response.

Pieper's Questions to Us (Feb 21, 2026)

He wrote: "to sort things out I'd have to know more about the different aspects." These are his exact questions:

#His QuestionStatus
1What is your main issue?Answered in letter. Nervousness, agitation, circular thoughts, can't focus, can't communicate.
2What is your assessment on the Bell scale?Answered — said we're not sure, described her state, asked him to help rate it.
3Are you still adhering to any remedies on my treatment plan or what exactly has changed since when and why?Answered — not following full protocol, only Mg + NAC + clonazepam. Explained December crisis timeline.
4What protocol are you on at the moment?Answered — full current list provided.
5Are you still following the dietary recommendations?Answered — partially.
6What works and what doesn't?Answered — detailed breakdown of each treatment.
7Are there any new blood values?Answered — Jan 9 labs sent. New labs drawn, results pending.
8Could I send you a test-set for GABA and Serotonine (in urine) to Spain for you sending it back to Germany by express?Answered — YES. Address provided.
9Are you still on the TMS?Answered — paused after ~30 sessions, believed it worsened state.

Our Questions to Pieper

Questions we asked in the March 23 letter, awaiting his answers:

#TopicWhat We Asked
1Nicotine + low estrogenIs it safe to start nicotine patches when estrogen is very low? Should we fix estrogen first?
2Estrogen / ProgesteroneNo period 5 months → then 2 periods in one month. Gynaecologist suggested supplementation. Could hormonal imbalance be driving the nervous state?
3Iron and symptomsCould ferritin 9.98 alone be causing the nervousness and exhaustion? Continue infusions?
4TMS damageCould 30 TMS sessions have caused harm? Avoid entirely or was it wrong timing?
5CUN Pamplona testsPharmacogenomics done. They wanted MRI+contrast, EEG, lumbar puncture. Should we proceed?
6Clonazepam taperShe believes clonazepam makes her worse. When to start tapering from 0.6mg? She tried Daridorexant briefly, had side effects. She sleeps normally now.
7Residential programEnglish-speaking program for FQAD? Looked at Sea Recovery — not FQAD-specific.
8Online consultationCan he do a video call with Veronika so she feels someone is in charge of the plan?

Still Needs to Be Sent

Visual Snow checklist — Veronika needs to review symptoms from his PDF and send her assessment.
New blood results — blood drawn, waiting for lab results, will forward to Pieper.
Pharmacogenomics results — from CUN Pamplona, when received.
09 · Patient Data

Veronika Pogrebova

FieldValue
Full nameVeronika Pogrebova
Date of birth14 October 1992 (age 33)
Weight / Height58 kg / 175 cm
ProfessionTattoo artist (currently not working)
Marital statusMarried
Children2 sons — Aang (born 2016) and Luca (born 2023)
LanguagesRussian, Ukrainian, English
AddressCarrer Costa den Bandina 31, 17310 Lloret de Mar, Spain
Phone+34 641 022 283
InsuranceAXA

Husband / Primary Advocate

FieldValue
NameAnton Zinoviev
Phone+34 641 022 317
Emaila.zinoviev@me.com
LanguagesRussian, Ukrainian, English

Doctors Involved

DoctorRoleContact
Dr. Stefan PieperLead — FQAD specialist, integrative medicinekontakt@praxisdrpieper.de · Eichhornstr. 7, 78464 Konstanz · +49 7531 61133

Key Lab Values (Jan 9, 2026)

MarkerValueNote
Ferritin9.98Was 4 before infusions. Critical — normal 30-100.
Iron Saturation13.19%Low — normal 20-50%.
GGT54Elevated.
AST39Borderline. Was ×5 during escitalopram.
Vitamin D26.1Low — target 40-60.
10 · Execute

Action Plan

  • DONE
    Reply to Pieper — sent March 23
  • NEXT
    Buy 7mg nicotine patches + tape + Ambroxol 75mg — but check Pieper's reply re: estrogen first
  • NEXT
    Get new blood results — already drawn, waiting for lab
  • THIS WEEK
    Veronika: review Visual Snow symptoms — send follow-up to Pieper
  • THIS WEEK
    Complete 5th iron infusion
  • DAILY
    Polyvagal + breathing exercises (5 min minimum)
  • WHEN RESULTS
    Send new labs to Pieper — iron panel + estrogen
  • WHEN PIEPER REPLIES
    Start nicotine patches — cautious protocol (¼ × 2 weeks)
  • WHEN PIEPER REPLIES
    Clarify Daridorexant / clonazepam taper plan
  • ONGOING
    Clonazepam stable 0.6mg. TMS paused. No SSRIs.

Timeline

PeriodActions
Wks 1-2Nicotine ¼. Ambroxol 10d. Reply. Iron. Breathing.
Wks 3-6Nicotine ½. B1. GABA test. Report Pieper wk4.
Wks 6-8Assess. Plan taper. Daridorexant.
Mo 3-6Slow taper. Neuroplasticity. Reassess.
11 · Email Log

Full Correspondence with Dr. Pieper

Complete chronological log of all email exchanges between Anton Zinoviev and Dr. Stefan Pieper (kontakt@praxisdrpieper.de).

~10 Dec 2025
Anton → Pieper: First Contact
Initial email to kontakt@praxisdrpieper.de describing Veronika's case — FQAD after IV levofloxacin (Jan 2024, Cromwell Hospital London), severe psychiatric symptoms, multiple failed medication attempts. Requested consultation.
~12 Dec 2025
Pieper → Anton: Reply + Offer
Dr. Pieper responds. Offers individual therapy plan for €293 via PayPal. Consultation is email-only (no video/phone). Sends his FQAD Questionnaire with Bell Scale on the last page for Veronika to fill out.
14 Dec 2025
Anton → Pieper: Questionnaire + Payment
Sent: filled FQAD Questionnaire (Bell Scale answer: ~40 = can do light work 3-4 hours with rest periods), medical brief document ("veronika_brief.pdf"), and €293 PayPal payment.
18 Dec 2025
Pieper → Anton: Full Therapy Plan
Complete package received:
1. Therapy letter with diagnosis: FQAD, ICD E72.8, GABA metabolic disorder, hypervigilance.
2. Supplement protocol table (~15 items with AM/Noon/PM/Night schedule).
3. Nicotine patch therapy PDF with research papers (Sanders 2022, Leitzke 2023).
4. Visual Snow syndrome PDF for symptom assessment.
5. Separate message: "and please don't take SSRIs anymore!!!"
14 Feb 2026
Anton → Pieper: Deterioration Update
Detailed email about everything that happened since receiving the plan:
• Nicotine patches NOT started yet
• Cold-turkey clonazepam disaster (Dec 28 → ER, kindling)
• Clonazepam tripled to 0.6mg/day
• TMS started (~30 sessions) — appeared to worsen state, paused
• 4 of 5-6 IV iron infusions completed
• Veronika's continued low state: agitation, nervousness, circular thoughts
• Asked about: nicotine safety, CBT, residential programs, estrogen
21 Feb 2026
Pieper → Anton: "Sounds Really Dramatic"
"Dear Veronica and Anton, this sounds really dramatic and like a severe deterioration of your condition."

Modified nicotine protocol — MORE CAUTIOUS: ¼ patch daily × 2 weeks (not 3 days), then ½ patch × 4 weeks.

Asked 9 specific questions:
1. What is your main issue?
2. Bell scale assessment?
3. Still on treatment plan? What changed?
4. Current protocol?
5. Following diet?
6. What works / what doesn't?
7. New blood values?
8. Can I send GABA/Serotonin urine test to Spain?
9. Still on TMS?

Later same day: sent "???" — no reply from our side yet at that point.
23 Mar 2026
Anton → Pieper: Full Reply
Comprehensive reply answering all 9 questions + 7 new questions from our side:
Answers sent: main issue (nervousness, agitation, circular thoughts), Bell Scale (~40 described), treatment plan status (only Mg + NAC + clonazepam, not full protocol), current protocol list, diet partially followed, what works/doesn't, Jan 9 labs, YES to GABA test (address provided), TMS paused after ~30 sessions.

Our questions: nicotine + low estrogen safety, estrogen/progesterone issues (5mo amenorrhea then 2 periods), iron and symptoms, TMS damage, CUN Pamplona tests, clonazepam taper, residential program, online video consultation request.

Shared case file: veronika.dscff.es
Status: Awaiting response.
📧
7 exchanges total. Last message sent March 23. Awaiting Pieper's reply to answers + 7 questions.
Still pending from our side:
• Visual Snow symptom checklist (Veronika needs to review)
• New blood results (blood drawn, waiting for lab)
• Pharmacogenomics results (from CUN Pamplona)
12 · Sources

References & Contacts

Research

2022
Sanders et al.

nAChR blockade by FQ metabolites

ACS Chem. Neurosci. →
2023
Leitzke

Nicotine therapy for FQAD — up to full remission

Bioelectronic Medicine →
Course
Dr. Eleanor Stein

Neuroplasticity program

eleanorsteinmd.ca →
Course
Gupta Program

Brain retraining · Free 28-day trial

guptaprogram.com →

Documents

PDF
FQAD Protocol
Download →
PDF
Nicotine Therapy
Download →
PDF
Visual Snow
Download →
PDF
FQAD Questionnaire
Download →
PDF
Medical Brief
Download →
Personal medical reference. All decisions with Dr. Pieper.
veronika.dscff.es · March 2026