Fluoroquinolone-Associated Disability — treatment plan by Dr. Stefan Pieper, Integrative Medicine, Konstanz.
| Finding | Detail |
|---|---|
| Diagnosis | FQAD — Fluoroquinolone-Associated Disability |
| ICD | E72.8 — GABA metabolic disorder |
| Focus | Neuropsychiatric |
| Drug | Levofloxacin IV, 2d, Jan 2024, Cromwell Hospital London |
GABA = brain's calming neurotransmitter. FQs block GABA receptors → anxiety, hypervigilance, insomnia, panic, depression.
FQ metabolites block nAChRs → cognitive fog, fatigue, mood, sleep. Proven: Sanders 2022.
7mg, cover ¾ tape. + Ambroxol 75mg × 10 days.
If no improvement after 4 wks → Ambroxol 10 more days.
Much slower given deterioration.
Total 4-8 wks. Report Pieper at wk 4.
| Remedy | AM | Noon | PM | Night | Notes |
|---|---|---|---|---|---|
| MVM-A Antioxidant | 1 | 1 | Allergy Research | ||
| D3 5000+K2 200mcg | 1 | w/ meals | |||
| Omega-3 algae | 2 | +linseed oil | |||
| CoQ10 200 | 1 | +CDP-Choline 250 | |||
| Mg Glycinate 100 | 1 | 1 | 1 | +Ca 1-2g | |
| Mg L-Threonate 2000 | 1 | 1-2 | =144mg | ||
| Spermidine 1.2mg | 1 | 1 | 1 | or wheatgerm | |
| Theanine+Tyrosine+5HTP+Taurine | 1-2 | +Ashwagandha | |||
| SAMe 400-500 | 1 | (1) | +GABA 750-1000 | ||
| Daridorexant 50 | 1 | benzo taper | |||
| Pregnenolone 50 | 1 | +Pomegranate | |||
| NMN 500→NAD+ | 1 | 4-12 wks |
3-wk high-dose. Neuroprotective.
0.6mg/day now. She believes clonazepam makes her worse and wants off. Tried Daridorexant briefly — had some side effects. She sleeps normally now without problems. Taper timing: waiting for Pieper's guidance.
Polyvagal, somatic tracking, slow breathing.
Pixelated/flickering dots, TV static, all lighting.
Imprints persist. Moving objects leave trails.
Cobwebs indoors. WBC on wiggly paths.
Random flashes. Light painful.
Low light trouble. Circles/rays. Ghost images.
Heartbeat vision. Heat-haze. Washed out. Patterns shimmer.
62% of VS patients.
Detached. Dreamlike. Confusion.
Spinning. Involuntary.
He wrote: "to sort things out I'd have to know more about the different aspects." These are his exact questions:
| # | His Question | Status |
|---|---|---|
| 1 | What is your main issue? | Answered in letter. Nervousness, agitation, circular thoughts, can't focus, can't communicate. |
| 2 | What is your assessment on the Bell scale? | Answered — said we're not sure, described her state, asked him to help rate it. |
| 3 | Are you still adhering to any remedies on my treatment plan or what exactly has changed since when and why? | Answered — not following full protocol, only Mg + NAC + clonazepam. Explained December crisis timeline. |
| 4 | What protocol are you on at the moment? | Answered — full current list provided. |
| 5 | Are you still following the dietary recommendations? | Answered — partially. |
| 6 | What works and what doesn't? | Answered — detailed breakdown of each treatment. |
| 7 | Are there any new blood values? | Answered — Jan 9 labs sent. New labs drawn, results pending. |
| 8 | Could I send you a test-set for GABA and Serotonine (in urine) to Spain for you sending it back to Germany by express? | Answered — YES. Address provided. |
| 9 | Are you still on the TMS? | Answered — paused after ~30 sessions, believed it worsened state. |
Questions we asked in the March 23 letter, awaiting his answers:
| # | Topic | What We Asked |
|---|---|---|
| 1 | Nicotine + low estrogen | Is it safe to start nicotine patches when estrogen is very low? Should we fix estrogen first? |
| 2 | Estrogen / Progesterone | No period 5 months → then 2 periods in one month. Gynaecologist suggested supplementation. Could hormonal imbalance be driving the nervous state? |
| 3 | Iron and symptoms | Could ferritin 9.98 alone be causing the nervousness and exhaustion? Continue infusions? |
| 4 | TMS damage | Could 30 TMS sessions have caused harm? Avoid entirely or was it wrong timing? |
| 5 | CUN Pamplona tests | Pharmacogenomics done. They wanted MRI+contrast, EEG, lumbar puncture. Should we proceed? |
| 6 | Clonazepam taper | She believes clonazepam makes her worse. When to start tapering from 0.6mg? She tried Daridorexant briefly, had side effects. She sleeps normally now. |
| 7 | Residential program | English-speaking program for FQAD? Looked at Sea Recovery — not FQAD-specific. |
| 8 | Online consultation | Can he do a video call with Veronika so she feels someone is in charge of the plan? |
| Field | Value |
|---|---|
| Full name | Veronika Pogrebova |
| Date of birth | 14 October 1992 (age 33) |
| Weight / Height | 58 kg / 175 cm |
| Profession | Tattoo artist (currently not working) |
| Marital status | Married |
| Children | 2 sons — Aang (born 2016) and Luca (born 2023) |
| Languages | Russian, Ukrainian, English |
| Address | Carrer Costa den Bandina 31, 17310 Lloret de Mar, Spain |
| Phone | +34 641 022 283 |
| Insurance | AXA |
| Field | Value |
|---|---|
| Name | Anton Zinoviev |
| Phone | +34 641 022 317 |
| a.zinoviev@me.com | |
| Languages | Russian, Ukrainian, English |
| Doctor | Role | Contact |
|---|---|---|
| Dr. Stefan Pieper | Lead — FQAD specialist, integrative medicine | kontakt@praxisdrpieper.de · Eichhornstr. 7, 78464 Konstanz · +49 7531 61133 |
| Marker | Value | Note |
|---|---|---|
| Ferritin | 9.98 | Was 4 before infusions. Critical — normal 30-100. |
| Iron Saturation | 13.19% | Low — normal 20-50%. |
| GGT | 54 | Elevated. |
| AST | 39 | Borderline. Was ×5 during escitalopram. |
| Vitamin D | 26.1 | Low — target 40-60. |
| Period | Actions |
|---|---|
| Wks 1-2 | Nicotine ¼. Ambroxol 10d. Reply. Iron. Breathing. |
| Wks 3-6 | Nicotine ½. B1. GABA test. Report Pieper wk4. |
| Wks 6-8 | Assess. Plan taper. Daridorexant. |
| Mo 3-6 | Slow taper. Neuroplasticity. Reassess. |
Complete chronological log of all email exchanges between Anton Zinoviev and Dr. Stefan Pieper (kontakt@praxisdrpieper.de).